Mechanismus und Selektivität des Alkali-Ionentransportes in Modell-Membranen in Gegenwart des Antibioticums Valinomycin
✍ Scribed by H.-K. Wipf; A. Olivier; W. Simon
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- German
- Weight
- 215 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
Selective transport of potassium ions through synthetic membranes impregnated with valinomycin in octane‐2‐ol in the presence of equal amounts of K^+^ and Na^+^ or Li^+^ ions is induced on application of a potential difference across these membranes. By using ^14^C‐labelled valinomycin it is shown that transport of potassium ions is accompanied by an equivalent transport of valinomycin within the membrane, consistent with the formation of a 1 : 1 complex of K^+^ with valinomycin. The exchange of ligands is shown to occur during the transport process so that a carrier‐relay mechanism, as proposed earlier for macrotetrolide‐mediated potassium transport, accounts for all experimental results on the bulk membranes studied.