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Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation

✍ Scribed by Mahmoud M. Iravani; Peter Jenner


Publisher
Springer
Year
2011
Tongue
English
Weight
472 KB
Volume
118
Category
Article
ISSN
1435-1463

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## Abstract Dyskinesia, secondary to dopamine replacement therapy, is the major complication of currently available therapies for Parkinson's disease. Alpha~2~ adrenoceptor antagonists, such as idazoxan, can significantly reduce levodopa‐induced dyskinesia in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydr