Mechanisms underlying lack of insulin-like growth factor-binding protein-3 expression in non-small-cell lung cancer
โ Scribed by Chang, Yoon Soo; Wang, Luo; Suh, Young-Ah; Mao, Li; Karpen, Saul J; Khuri, Fadlo R; Hong, Waun Ki; Lee, Ho-Young
- Book ID
- 110068949
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 403 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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The mitogenic effects of insulin-like growth factors (IGFs) are regulated by a family of insulin-like growth factor binding proteins (IGFBPs). One member of this family, IGFBP-3, mediates the growth-inhibitory and apoptosis-inducing effects of a number of growth factors and hormones such as transfor
Insulin-like growth factor binding protein-3 (IGFBP-3) inhibits the mitogenic and antiapoptotic activity of insulin-like growth factor (IGF) by blocking the binding of IGF to its receptor. However, under certain circumstances, IGFBP-3 can enhance the activity of IGF by protecting IGF from degradatio