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Mechanisms of resistance to 6-thioguanine in a murine pancreatic tumor

โœ Scribed by Bih-Fang Pan; Teresa S. Priebe; J. Arly Nelson


Book ID
104886568
Publisher
Springer
Year
1992
Tongue
English
Weight
432 KB
Volume
29
Category
Article
ISSN
0344-5704

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โœ Michihiro C. Yoshida; Yoshiaki Kodama ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Springer ๐ŸŒ English โš– 421 KB

A mutant human lymphoblastoid cell line, Raji-TG, resistant to 10~zg 6-thioguanine (TG)/ml was produced from wild-type cells after exposure to ethylmethane sulfonate. The Raji-TG cells showed their failure to incorporate 3H-hypoxanthine, only 2% as much hypoxanthine guanine phosphoribosyl transferas