Intrathymic injection of guinea pig myelin basic protein (MBP) or the immunodominant, encephalitogenic fragment of MPB, 68-86, without otherwise compromising the peripheral lymphocyte pool in adult LEW rats, dramatically inhibits onset of experimental allergic encephalomyelitis (EAE) caused by the u
MECHANISMS OF RECOVERY AND ACQUIRED RESISTANCE IN LEWIS RAT EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
β Scribed by Willenborg, David O
- Book ID
- 109864507
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1981
- Weight
- 667 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0004-945X
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π SIMILAR VOLUMES
Rats of the Fischer 344 (F344) strain are resistant to experimental allergic encephalomyelitis (EAE) induced by active immunization with guinea pig myelin basic protein (MBP) in complete Freund's adjuvant whereas Lewis (LEW) rats are susceptible even though both strains share the same I-A-like class
To evaluate the immunomodulating activity of methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk) in the development of experimental allergic encephalomyelitis (EAE), two strains of rats, one highly susceptible to EAE (Lewis rats) and the other relatively resistant to the disease (Wistar