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Mechanisms of reactions of ring-substituted bis(1-aziridinyl) phosphinyl urethan antineoplastic agents

✍ Scribed by C. K. Navada; Z. F. Chmielewicz; T. J. Bardos


Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
579 KB
Volume
59
Category
Article
ISSN
0022-3549

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## Abstract The double Mannich reaction of cyclic β‐keto esters with bis(alkoxymethyl)alkylamines provides an efficient and versatile method for the construction of azabicyclo[3.3.1]nonanes and azabicyclo[3.2.1]octanes. The optimum conditions for efficient reaction involve use of the activator tric