Mechanisms of Protein Synthesis: Structure-Function Relations, Control Mechanisms, and Evolutionary Aspects

✍ Scribed by P. L. Wollenzien, C. F. Hui, C. Kang, R. F. Murphy, C. R. Cantor (auth.), Prof. Dr. Engin Bermek (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1985
• Tongue: English
• Leaves: 225
• Series: Proceedings in Life Sciences
• Edition: 1
• Category: Library

✦ Synopsis

This volume contains the papers presented at the international symposium on "Molecular Mechanisms in Protein Synthesis" held on September 26-27, 1983 at the Beyaz Ko§k in Emirgan, Bosphorus, Istanbul. The symposium aimed to create a medium for information exchange and discussions regarding the current developments in the area of protein syn­ thesis. To ensure an informal yet scientifically stimulating and productive atmosphere providing opportunity for relaxed and speculative discussions, the number of presentations was limited to twenty and that of attendants to about sixty. The emphasis in the symposium was laid on structure-function relations in the prokaryotic protein synthesizing systems and on the control mechanisms of eukaryotic protein synthesis, in particular, during chain initia­ tion. Other issues like evolutionary aspects of protein synthesis, translational components genes and proofreading were covered as well. The manuscripts represent the extended accounts of the oral presenta­ tions, and it has been aimed with the concluding remarks at the end of the volume to give a summarizing view of the presentations and the discussions.

✦ Table of Contents

Front Matter....Pages I-IX
Front Matter....Pages 1-1
RNA Structure, Free and on the Ribosome, as Revealed by Chemical and Enzymatic Studies....Pages 2-22
Studies of E. coli Ribosomes Involving Fluorescence Techniques....Pages 23-39
Ribosomal Components of the Peptidyl Transferase Center....Pages 40-48
Front Matter....Pages 49-49
Interaction Between Elongation Factor Tu and Aminoacyl-tRNA....Pages 50-60
Recognition of Aminoacyl-tRNA by Bacterial Elongation Factor Tu....Pages 61-74
Front Matter....Pages 75-75
tRNA Binding to and Topographical Arrangement on E.coli Ribosomes....Pages 76-89
Front Matter....Pages 91-91
Studies on Structural Dynamics of the Translating Ribosome....Pages 92-104
Front Matter....Pages 105-105
The Effect of “In Vivo“ Incorporation of α-Aminobutyric Acid into E. coli Proteins....Pages 106-118
Front Matter....Pages 119-119
A Direct Correlation Between the Affinity of a Given mRNa for Eukaryotic Initiation Factor 2 and its Ability to Compete in Translation....Pages 120-134
Regulation of Initiation Factor Activity....Pages 135-143
Translational Control of Protein Synthesis in Reticulocyte Lysates by eIF-2α Kinases....Pages 144-158
Calcium Ions and Phospholipid Activate a Translational Inhibitor in Reticulocyte Lysates....Pages 159-168
High pO 2 -Promoted Activation of a Translational Inhibitor in Rabbit Reticulocytes: Role of the Oxidation State of Sulfhydryl Groups....Pages 169-177
Front Matter....Pages 179-179
Guanine Nucleotide Binding to Eukaryotic Elongation Factor 2: A Possible Control Mechanism of Eukaryotic Chain Elongation....Pages 180-191
Front Matter....Pages 193-193
Some Interesting Features of a Halobacterial Gene and its mRNA....Pages 194-200
Cell Evolution and the Selective Action of Translation Inhibitors....Pages 201-210
Concluding Remarks....Pages 211-215
Back Matter....Pages 217-220

✦ Subjects

Biochemistry, general; Cell Biology