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Mechanisms of protein stabilization in the solid state

โœ Scribed by Liuquan (Lucy) Chang; Michael J. Pikal

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
390 KB
Volume
98
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The solid state is preferred for many proteins due to their marginal stability in solution. However, even in the solid state, chemical and physical degradation can occur on the time scale of the drying process, distribution and use. This review summarizes the major degradation pathways of proteins in the solid state and the corresponding stabilization strategies. Specially, this review discusses the mechanisms of protein stabilization in the solid state. Understanding the mechanisms of protein stabilization is critical to efficient protein formulation development in the pharmaceutical industry.

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