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Mechanisms of petroleum hydrocarbon toxicity: Functional changes in rat liver mitochondria after exposure to a prudhoe bay crude oil

โœ Scribed by Khan, Sumsullah; Payne, Jeremiah F.; Rahimtula, Anver D.


Book ID
120159086
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
417 KB
Volume
32
Category
Article
ISSN
0378-4274

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Administration of Prudhoe Bay crude oil (PBCO) to rats resulted in an abrupt drop in liver mitochondrial and microsomal ATP-dependent calcium uptake activity. Also, in vitro incubations of either mitochondria or microsomes in the presence of a dimethyl sulfoxide (DMSO) extract of PBCO resulted in a

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Administration of a Prudhoe Bay crude oil (PBCO) to rats has been shown to (a) inhibit platelet aggregation induced by adenosine diphosphate (ADP), arachidonic acid, or epinephrine and (b) induce benzo-a-pyrene hydroxylase (BPH) in the liver and small intestine. Maximum inhibition of aggregation (90