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Mechanisms of Na+-K+-ATPase phosphorylation by PKC in the medullary thick ascending limb of Henle in the rat

✍ Scribed by ClaudiaA. Bertuccio; SamX. Cheng; ElviraE. Arrizurieta; RodolfoS. Martín; FernandoR. Ibarra


Publisher
Springer
Year
2003
Tongue
English
Weight
365 KB
Volume
447
Category
Article
ISSN
0031-6768

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The maximal urinary osmolality that can be reached by the kidney is reduced with age. This may be due to impaired NaC1 transport by the medullary thick ascending limb of Henle's loop, which is part of the renal concentrating mechanism and is modulated by antidiuretic hormone (ADH). We therefore test