𝔖 Bobbio Scriptorium
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Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors

✍ Scribed by Beck, William T.


Book ID
121914180
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
736 KB
Volume
17
Category
Article
ISSN
0305-7372

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## Abstract Salvicine, a novel topoisomerase II inhibitor and a diterpenoid quinone compound, exerts potent __in vitro__ and __in vivo__ antitumor effects. In our study, we show that salvicine effectively kills multidrug‐resistant (MDR) sublines, such as K562/A02, KB/VCR and MCF‐7/ADR, and parental