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Mechanisms of macrophage cytotoxicity in IL-2 and IL-12 mediated tumour regression

✍ Scribed by Agnieszka Masztalerz; Nico Van Rooijen; Willem Den Otter; Linda A. Everse

Book ID
105966637
Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
313 KB
Volume
52
Category
Article
ISSN
0340-7004

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High dose [ > 1 nM or 30 IU] interleukin-2 (IL-2) can induce MHC-unrestricted killing from various lymphoid populations. Although it is well established that CD16+ NK cells are the major source of blood-derived LAK precursors, other lymphoid cells, including several CD3+ T subsets can be a source of