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Mechanisms of loss of HLA class I expression on colorectal tumor cells

✍ Scribed by M. Browning; F. Petronzelli; D. Bicknell; P. Krausa; A. Rowan; S. Tonks; N. Murray; J. Bodmer; W. Bodmer

Book ID
115096653
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
675 KB
Volume
47
Category
Article
ISSN
0001-2815

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## Abstract Alterations in the surface expression of HLA class I molecules have been described as a strategy of tumors to evade recognition by cytotoxic T cells. We detected complete loss of HLA class I antigen presentation for 2 tumor cell lines from 1 melanoma patient, the first originated from a