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Mechanisms of leukotriene-induced contractions of guinea pig airways: Leukotriene C4has a potent direct action whereas leukotriene B4acts indirectly

✍ Scribed by DAHLÉN, SVEN-ERIK ;HEDQVIST, PER ;WESTLUND, PÄR ;GRANSTRÖM, ELISABETH ;HAMMARSTRÖM, SVEN ;LINDGREN, JAN ÅKE ;RÅDMARK, OLOF


Book ID
114868353
Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
790 KB
Volume
118
Category
Article
ISSN
0001-6772

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✍ M. Kurosawa; H. Tsukagoshi 📂 Article 📅 1993 🏛 Elsevier 🌐 English ⚖ 350 KB

SUMMARY: We studied the effect of iv administration of leukotriene (LT) \(\mathrm{C}_{4}\) on bronchial responsiveness to histamine and airway wall thickening in guinea-pigs. The infusion of \(3 \mu \mathrm{g} / \mathrm{kg} \mathrm{LTC}\) for \(1 \mathrm{~h}\) induced an increase of the relative thi