Mechanisms of Lactone Hydrolysis in Neutral and Alkaline Conditions
✍ Scribed by Gómez-Bombarelli, Rafael; Calle, Emilio; Casado, Julio
- Book ID
- 120567655
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 543 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-3263
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## Abstract Reaction rate constants for the hydrolysis of organic esters and amides were determined at temperatures of 100–240°C in aqueous solutions buffered at pH values between 5.5 and 7.3. Experiments are modeled assuming alkaline hydrolysis with a thermodynamic solution model included to accou
of the acetyl group had an overall negative effect on the antimalarial potency of this series of thiosemicarbazones. Antibacterial Activity-In the assessment of the antibacterial activity of the 2-(a-hydroxyacetyl)pyridine thiosemicarbazones (Table Ill), the strong inhibitory effect of the 2-acetyl