Quantitative determination of the estrogen receptor (estrophilin) content of a n excised tumor specimen provides information useful in selecting the type of systemic therapy best suited to the individual patient with advanced breast cancer. Women whose tumors contain low or negligible amounts of est
Mechanisms of hormone resistance in breast cancer
โ Scribed by Kathryn B. Horwitz
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 989 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
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Recent evidence suggests that the progression to hormone resistance in some breast tumors is due to mutations in the estrogen receptor (ER). Various types of ER variants have been found in breast cancer biopsies and breast cancer cell lines. The ER variants include dominant-positive receptors that a
Attempts have been made to develop sublines of MCF-7 cells resistant to the growth-inhibitory actions of medroxyprogesterone acetate (MPA), dexamethazone (DEX), antioestrogens or high-dose oestradiol (Ed by prolonged exposure to high hormone concentrations. While high degrees of resistance to MPA, D