𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mechanisms of HIV-1 Nef Function and Intracellular Signaling

✍ Scribed by Foster, John L.; Denial, Sarah J.; Temple, Brenda R. S.; Garcia, J. Victor

Book ID
107381759
Publisher
Springer US
Year
2011
Tongue
English
Weight
411 KB
Volume
6
Category
Article
ISSN
1557-1890

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Nef is a regulatory protein of the human and simian immunodeficiency viruses (HIV and SIV) whose role in infection and the viral life cycle are not fully understood. In T‐lymphocytes Nef down‐regulates cell‐surface CD4, and has been implicated in an increase in infectivity at low primary viral isola