Mechanisms of glutamate release from astrocytes
β Scribed by Erik B. Malarkey; Vladimir Parpura
- Book ID
- 116765041
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 474 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0197-0186
No coin nor oath required. For personal study only.
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## Abstract We have previously demonstrated that human astrocytes are GABAergic cells. Throughout the adult human brain, they express the GABA synthesizing enzyme GAD 67, the GABA metabolizing enzyme GABAβT, and the GABA~A~ and GABA~B~ receptors. GABA modulates the actions of microglia, indicating
Astrocytes are thought to control extracellular glutamate concentrations ([Glu] o ) in the brain, thereby protecting neurons from excitotoxic injury. We investigated the effects of metabotropic glutamate receptor (mGluR) agonists on glutamate transport and [Glu] o in primary hippocampal astrocytic c