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Mechanisms of Glucocorticoid-receptor-mediated Repression of Gene Expression

✍ Scribed by Jeffrey C Webster; John A Cidlowski

Book ID
117700576
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
182 KB
Volume
10
Category
Article
ISSN
1043-2760

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Glucocorticoids exert pleiotropic effects, among which negative regulation of transcription has been recognized as of crucial importance. While glucocorticoids induce phosphoenolpyruvate carboxykinase (PEPCK) gene expression in liver cells, it represses gene activity in adipose cells. We used the 3T