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Mechanisms of factor VIIa-catalyzed activation of factor VIII

โœ Scribed by T. SOEDA; K. NOGAMI; T. MATSUMOTO; K. OGIWARA; M. SHIMA


Book ID
109154497
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
446 KB
Volume
8
Category
Article
ISSN
1538-7933

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Activation of factor VIII and mechanisms
โœ Philip J Fay ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 495 KB

The factor VIII procofactor circulates as a metal ion-dependent heterodimer of a heavy chain and light chain. Activation of factor VIII results from limited proteolysis catalyzed by thrombin or factor Xa, which binds the factor VIII substrate over extended interactive surfaces. The proteases efficie