Activation of factor VIII and mechanisms
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Philip J Fay
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Article
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2004
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Elsevier Science
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English
โ 495 KB
The factor VIII procofactor circulates as a metal ion-dependent heterodimer of a heavy chain and light chain. Activation of factor VIII results from limited proteolysis catalyzed by thrombin or factor Xa, which binds the factor VIII substrate over extended interactive surfaces. The proteases efficie