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Mechanisms of cycloheximide-induced apoptosis in liver cells

โœ Scribed by Alice V Alessenko; Peter Ya Boikov; Galina N Filippova; Alexey V Khrenov; Anatoliy S Loginov; Elena D Makarieva


Book ID
117108251
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
575 KB
Volume
416
Category
Article
ISSN
0014-5793

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Cells of the human promyelocytic HL-60 line, when treated with a variety of antitumor agents in the presence of the protein synthesis inhibitor cycloheximide (CHX), or with CHX alone, rapidly undergo apoptosis ("active cell death"). It is presumed, therefore, that such cells are "primed" to apoptosi