Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy
β Scribed by Hugo F. Mendes; Jacqueline van der Spuy; J. Paul Chapple; Michael E. Cheetham
- Book ID
- 116757927
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 248 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1471-4914
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## Abstract Retinitis pigmentosa (RP) is a heterogeneous group of diseases in which one of a wide variety of mutations selectively causes rod photoreceptor cell death. After rods die, cone photoreceptors gradually die resulting in blindness. Antioxidants reduce cone cell death in __rd1__/__rd1__ mi
## Abstract Retinitis pigmentosa (RP) is a prevalent cause of blindness caused by a large number of different mutations in many different genes. The mutations result in rod photoreceptor cell death, but it is unknown why cones die. In this study, we tested the hypothesis that cones die from oxidati