✦ LIBER ✦

Mechanisms of cell death and neuroprotection I

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 215 KB
Volume: 9
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870090702

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✦ Synopsis

Although the ultimate causes of Parkinson's disease (PD) are not yet identifed, several biochemical abnormalities have recently been identified which together may represent the terminal events which result in dopaminergic cell death in the substantia nigra. Oxidative stress and damage, and mitochondria1 complex I deficiency have recently been discovered in PD nigra. These biochemical abnormalities together with elevated iron and dopamine autooxidation may represent the fmal common pathway resulting in nigral neuronal death. The contribution of each of these, and the sequence in which they act will provide important clues to the aetiology of PD.

To date, it has been assumed that Ngral newones die by necrosis. Evidence is now emerging, however, that the necessary elements are in place for nigral newones to die by apoptosis, although there is no direct evidence available to support this. Respiratory chain inhibitors

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