β Scribed by M. H. L. Green
No coin nor oath required. For personal study only.
Bacterial tester strains are available which can detect base pair substitution, frameshift and deletion mutations. I consider possible mechanisms for these types of event. I describe the four main types of DNA repair process operating in Escherichia coli and Salmonella typhimurium and how they may influence mutation: Means of modifying repair processes to increase the sensitivity of tester strains are discussed. The properties of some current strains are briefly described. I comment adversely on forward mutation systems and discuss aspects of the strategy and methodology of mutagenicity testing with bacteria.
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## Abstract The standard __Salmonella__ mutagenicity (Ames) tester strains are missing 15β119 genes due to the extended Ξ(__galβbioβuvrB__) mutations that render the strains excisionβrepair deficient (Ξ__uvrB__). We constructed strains of __Salmonella__ that are homologous to tester strains TA98 an