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Mechanisms of Autoinhibition and STI-571/Imatinib Resistance Revealed by Mutagenesis of BCR-ABL

✍ Scribed by Mohammad Azam; Robert R. Latek; George Q. Daley


Book ID
117269463
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
1020 KB
Volume
112
Category
Article
ISSN
0092-8674

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## Abstract ## BACKGROUND Although various mechanisms have been recognized as being associated with the development of resistance to imatinib mesylate in vitro and in clinical situations, their relative significance and contributions remain poorly understood, as is the sequence of events leading t