Mechanisms of aspirin chemoprevention of colorectal cancer
โ Scribed by H. Vainio; G. Morgan
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 506 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0378-7966
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Colorectal cancer is one of the major causes of cancer-related mortality in both men and women worldwide. This review focuses on preventing the initiation and promotion of neoplastic growth in colorectal cancer, particularly with natural dietary compounds. Chemoprevention is defined as the use of na
We have studied aspirin as a potential chemopreventive for colorectal cancer, completing Phase I studies on aspirin pharmacology and potential biomarker assays (prostaglandins, PGE 2 and PGF 2โฃ and cyclooxygenase modulation) in normal human subjects. These studies have determined the optimal dose of