Mechanisms of arsenic-induced cell transformation
โ Scribed by J. Carl Barrett; Patricia W. Lamb; T. C. Wang; Chang Te Lee
- Book ID
- 112936375
- Publisher
- Humana Press Inc
- Year
- 1989
- Tongue
- English
- Weight
- 535 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0163-4984
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๐ SIMILAR VOLUMES
Arsenic and its derivatives are naturally occurring metalloid compounds widely distributed in the environment. Arsenics are known to cause cancers of the skin, liver, lung, kidney, and bladder. Although numerous carcinogenic pathways have been proposed, the exact molecular mechanisms remain to be de
## Abstract In this study, we demonstrated that low levels (1.5 ฮผM) of arsenite induces B[a]Pโtreated lung cell transformation. We then used a proteomic approach to identify protein expression by ProteinChips, which could potentially be important for transformation induced by this toxic metal. Most