✦ LIBER ✦

Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer

✍ Scribed by Robert G. Uzzo; Naomi B. Haas; Paul L. Crispen; Vladimir M. Kolenko

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 393 KB
Volume: 112
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.23318

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✦ Synopsis

Abstract

New therapeutic strategies are needed to improve treatment outcomes in men with hormone‐refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis‐resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone‐refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance. Cancer 2008. © 2008 American Cancer Society.

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