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Mechanisms of antibody neutralization of botulinum neurotoxins

โœ Scribed by Marks, J.D.

Book ID
121815265
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
40 KB
Volume
68
Category
Article
ISSN
0041-0101

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โœ James D. Marks ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 186 KB

Monoclonal antibodies (mAbs) have been developed that bind to the toxin binding domain (H C ) of botulinum toxin type A. These mAbs recognize with high affinity nonoverlapping epitopes on native toxin. The potency of a combination of three of the mAbs is almost 100 times greater than that reported f