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Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models

✍ Scribed by Vitins, Alexa P.; Kienhuis, Anne S.; Speksnijder, Ewoud N.; Roodbergen, Marianne; Luijten, Mirjam; Ven, Leo T. M.

Book ID: 121548909
Publisher: Springer-Verlag
Year: 2014
Tongue: English
Weight: 485 KB
Volume: 88
Category: Article
ISSN: 0340-5761
DOI: 10.1007/s00204-014-1211-0

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The infant mouse as a in vivo model for

The infant mouse as a in vivo model for the detection and study of DNA damage–induced changes in the liver

✍ Randall Reynolds; Sam Witherspoon; Tony Fox 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 239 KB

## Abstract The present work describes the use of the infant (4‐wk‐old) mouse as an animal model for the study of DNA damage–induced G~1~ checkpoint response, changes in p53 protein levels, and multiple gene expression changes after DNA damage has been induced in the liver. Hepatocytes in the infan