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Mechanisms of Action of TGF-β in Cancer : Evidence for Smad3 as a Repressor of the hTERT Gene

✍ Scribed by HE LI; JUN-PING LIU


Book ID
111483290
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
112 KB
Volume
1114
Category
Article
ISSN
0890-6564

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Transcription of the alpha2(I) collagen gene (COL1A2) in fibroblasts is potently induced by transforming growth factor-beta (TGF-beta). Smad family proteins function as intracellular signal transducers for TGF-beta that convey information from the cell membrane to the nucleus. In the present study,