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Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells

✍ Scribed by N. Podechard; X. Tekpli; D. Catheline; J.A. Holme; V. Rioux; P. Legrand; M. Rialland; O. Fardel; D. Lagadic-Gossmann; V. Lecureur

Book ID
116924850
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
897 KB
Volume
206
Category
Article
ISSN
0378-4274

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## Abstract The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Judged by the inhibiting effect of wortmannin, phosphatidyl‐inositol‐3 (PI‐3) kinases su