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Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity

✍ Scribed by Marianne Fillet; Mohamed Bentires-Alj; Valerie Deregowski; Roland Greimers; Jacques Gielen; Jacques Piette; Vincent Bours; Marie-Paule Merville

Book ID: 113993483
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 364 KB
Volume: 65
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(03)00125-4

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CD95 and ceramide are known to be involved in the apoptotic mechanism. The triggering of CD95 induces a cascade of metabolic events that progressively and dramatically modifies the cell shape by intense membrane blebbing, leading to apoptotic bodies production. Although the CD95 pathway has been abu