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Mechanisms for recombination between stably integrated vector sequences in CHO cells

โœ Scribed by D. Hellgren; B. Lambert

Book ID
113193692
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
593 KB
Volume
215
Category
Article
ISSN
0027-5107

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## Abstract An amino acid sequence variant is defined as an unintended amino acid sequence change and contributes to product heterogeneity. Recombinant monoclonal antibodies (MAbs) are primarily expressed from Chinese Hamster Ovary (CHO) cells using stably transfected production cell lines. Selecti