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Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells

✍ Scribed by Fumiko Sekiguchi; Shino Saito; Kaori Takaoka; Hitomi Hayashi; Mami Nagataki; Keita Nagasawa; Hiroyuki Nishikawa; Hirofumi Matsui; Atsufumi Kawabata

Book ID
113488119
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
1003 KB
Volume
73
Category
Article
ISSN
0006-2952

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## Abstract Proteinase‐activated receptor‐1 (PAR1), upon activation, exerts prostanoid‐dependent gastroprotection, and increases prostaglandin E~2~ (PGE~2~) release through cyclooxygenase‐2 (COX‐2) upregulation in rat gastric mucosal epithelial RGM1 cells. However, there is a big time lag between t