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Mechanisms for methotrexate chemotherapy-induced bone growth defects and protective effects of folinic acid supplementary treatment

โœ Scribed by C.J. Xian; J. Cool; M. Scherer; C. Macsai; C. Fan; T. King; K. Georgiou; B. Foster

Book ID
116320148
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
74 KB
Volume
40
Category
Article
ISSN
8756-3282

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## Abstract Chemotherapy often induces bone growth defects in pediatric cancer patients; yet the underlying cellular mechanisms remain unclear and currently no preventative treatments are available. Using an acute chemotherapy model in young rats with the commonly used antimetabolite methotrexate (