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Mechanism of β1-integrin-mediated hepatoma cell growth involves p27 and S-phase kinase-associated protein 2

✍ Scribed by Hao Zhang; Iwata Ozaki; Toshihiko Mizuta; Tohru Yoshimura; Sachiko Matsuhashi; Akitaka Hisatomi; Jutaro Tadano; Takahiro Sakai; Kyosuke Yamamoto


Book ID
111722346
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
320 KB
Volume
38
Category
Article
ISSN
0270-9139

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio