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Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl)cytosine (HPMPC) in vero cells

✍ Scribed by Michele C. Connelly; Brian L. Robbins; Arnold Fridland


Book ID
115783644
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
386 KB
Volume
46
Category
Article
ISSN
0006-2952

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Synthesis of (S)-1-[3-hydroxy-2-(phospho
✍ U. J. Haynes; J. E. Swigor; J. J. Bronson πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 164 KB

## Abstract The synthesis of (S)‐[^14^C]HPMPC (4) is described. Heating [2‐^14^C]cytosine (1) in N, N‐dimethylformamide with (R)‐3‐0‐benzyl‐2‐0‐[(diethylphosphonyl)methyl]‐1‐0‐(methylsulfonyl) glycerol in the presence of cesium carbonate gave (S)‐1‐[3‐benzyloxy‐2‐(diethylphosphonylmethoxy) propyl]‐