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Mechanism of Ultraviolet B-Induced Cell Cycle Arrest in G2/M Phase in Immortalized Skin Keratinocytes with Defective p53

✍ Scribed by Mohammad Athar; Arianna L. Kim; Nihal Ahmad; Hasan Mukhtar; Jean Gautier; David R. Bickers

Book ID: 115586515
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 115 KB
Volume: 277
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.2000.3436

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## Abstract The tumor‐suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor‐suppressor activity by either causing cell‐cycle arrest (G~1~/S or G~2~/M) or inducing cells to undergo apoptosis. This function of wild‐type p53 as “guardia