Mechanism of thrombin inhibition by heparin cofactor II in the presence of dermatan sulphates, native or oversulphated, and a heparin-like dextran derivative

Beta2-glycoprotein I protects thrombin f

Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: Potentiation of this effect in the presence of anti–β2-glycoprotein I autoantibodies

✍ Soheila Rahgozar; Bill Giannakopoulos; Xiaokai Yan; Jiewei Wei; Jian Cheng Qi; R 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 1 views

## Abstract ## Objective Beta~2~‐glycoprotein I (β~2~GPI) is an important autoantigen in the antiphospholipid syndrome (APS). In vitro studies suggest that it may have multifaceted physiologic functions, since it displays both anticoagulant and procoagulant properties. We have previously reported