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Mechanism of the salutary effects of 17β-estradiol following trauma-hemorrhage: direct downregulation of Kupffer cell proinflammatory cytokine production

✍ Scribed by Yukihiro Yokoyama; Joachim F Kuebler; Takeshi Matsutani; Martin G Schwacha; Kirby I Bland; Irshad H Chaudry


Book ID
117700640
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
698 KB
Volume
21
Category
Article
ISSN
1043-4666

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## Abstract Studies have shown that administration of 17β‐estradiol prevents trauma‐hemorrhage‐induced increase in proinflammatory cytokine production by Kupffer cells and associated multiple organ injury. Since activation of peroxisome proliferator‐activated receptor γ (PPARγ) following ischemic c