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Mechanism of the metabolic acidosis of selective mineralocorticoid deficiency

✍ Scribed by DiTella, Philip J; Sodhi, Brijnandin; McCreary, James; Arruda, Jose A L; Kurtzman, Neil A

Book ID
109877301
Publisher
Nature Publishing Group
Year
1978
Tongue
English
Weight
824 KB
Volume
14
Category
Article
ISSN
0085-2538

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Hippurate participates in the correction
Hippurate participates in the correction of metabolic acidosis
✍ Dzúrik, Rastislav; SpustovÑ, Viera; KrivoőíkovÑ, Zora; GazdíkovÑ, Katarí πŸ“‚ Article πŸ“… 2001 πŸ› Nature Publishing Group 🌐 English βš– 478 KB

Hippurate (Hip), an endogenous conjugate, belongs to the group of uremic toxins. Hip stimulates P-independent glutaminase (PIG) localized at the proximal luminal membrane, desamidating glutamine with the formation of ammonia, a dominant and adaptive elimination product of H+. This appears to be impo