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Mechanism of the inhibition by cadmium of DNA synthesis in murine lymphocytes

โœ Scribed by T. Andranovich; I. Gray


Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
87 KB
Volume
4
Category
Article
ISSN
0192-0561

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๐Ÿ“œ SIMILAR VOLUMES


Inhibition of human DNA ligase I activit
โœ Shu Wei Yang; Frederick F. Becker; John Y. H. Chan ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 650 KB

Heavy metals, including zinc (Zn) and cadmium (Cd), are potentially important genotoxic agents in our environment. Here we report that human DNA ligase I, the major form of the enzyme in replicative cells, is a target for Zn and Cd ions. ZnCl2 at 0.8 mM caused complete inhibition of DNA ligase I act