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Mechanism of prostaglandin E2-induced arachidonic acid release in osteoblast-like cells: Independence from phosphoinositide hydrolysis

✍ Scribed by Kozawa, O.; Tokuda, H.; Miwa, M.; Takahashi, Y.; Ozaki, N.; Oiso, Y.

Book ID: 122904650
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 555 KB
Volume: 46
Category: Article
ISSN: 0952-3278
DOI: 10.1016/0952-3278(92)90038-K

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In a previous study, we have shown that endothelin-1 (ET-1) activates phospholipase D independently from protein kinase C in osteoblast-like MC3T3-E1 cells. It is well recognized that phosphatidylycholine hydrolysis by phospholipase D generates phosphatidic acid, which can be further degraded by pho