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Mechanism of polyamine inhibition of a leaf protease

โœ Scribed by E. Balestreri; P. Cioni; A. Romagnoli; S. Bernini; A. Fissi; R. Felicioli


Book ID
115707453
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
321 KB
Volume
255
Category
Article
ISSN
0003-9861

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Sequential inhibition of polyamine synth
โœ Raymond P. Warrell; Craig J. Coonley; Joseph H. Burchenal ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 337 KB

Both DFMO and methyl-GAG inhibit sequential enzymatic reactions in the pathway of polyamine biosynthesis. Since polyamines may be important factors in proliferation of cancer cells, we initiated a phase-I study of these agents in patients with advanced cancer. DFMO was given by mouth at a constant d