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Mechanism of poloxamer 407-induced hypertriglyceridemia in the rat

โœ Scribed by Thomas P. Johnston; Warren K. Palmer


Book ID
115783643
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
506 KB
Volume
46
Category
Article
ISSN
0006-2952

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The role of the fenestrated liver sinusoidal endothelial cells (LSECs) in the hepatic disposition of paracetamol was investigated in isolated perfused livers from rats treated with poloxamer 407 (P407), a surfactant that causes extensive defenestration of the LSECs. Bolus doses containing tracer amo