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Mechanism of Phosphorylation-Dependent Binding of APC to β-Catenin and Its Role in β-Catenin Degradation

✍ Scribed by Nam-Chul Ha; Takashi Tonozuka; Jennifer L. Stamos; Hee-Jung Choi; William I. Weis


Book ID
116753616
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
510 KB
Volume
15
Category
Article
ISSN
1097-2765

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Mannitol, which is a cell-impermeable and nontoxic polyalcohol, has been shown to be a useful tool for reversible opening of the blood-brain barrier (BBB). Despite successful clinical trials, the molecular mechanism of the mannitol-induced changes in cerebral endothelial cells (CECs) are poorly unde