Mechanism of p53 downstream effectors p21 and Gadd45 in DNA damage surveillance

Abrogation of apoptosis induced by DNA-d

Abrogation of apoptosis induced by DNA-damaging agents in human bladder-cancer cell lines with p21/WAF1/CIP1 and/or p53 gene alterations

✍ Takashi Kawasaki; Yoshihiko Tomita; Vladimir Bilim; Masayuki Takeda; Kota Takaha 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 570 KB

The p53-inducible cyclin-dependent kinase inhibitor, p2 I / WAFI/CIPI (p2I), plays a pivotal role in the GI arrest or apoptosis of cells expored to genotoxic stimuli. To determine whether p2 I is a putative tumor-suppressor gene, p2 I status was investigated in 4 human bladder-cancer cell lines of k