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Mechanism of oxidation of diazepam by Chloramine-B: A kinetic approach

✍ Scribed by N. Nanda; S. M. Mayanna; N. M. Made Gowda

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 167 KB
Volume: 30
Category: Article
ISSN: 0538-8066
DOI: 10.1002/(sici)1097-4601(1998)30:9<605::aid-kin1>3.0.co;2-w

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✦ Synopsis

The kinetics of the oxidation of diazepam (DZ) by Chloramine-B (CAB) has been studied in aqueous hydrochloric acid medium. The oxidation reaction follows the rate law:

The dependence of the reaction rate on temperature is studied and activation parameters for the rate-determining step are evaluated. The dielectric constant of the medium has a small effect on the rate. Ionic strength and the reaction product benzenesulfonamide have no effect on the reaction rate. The solvent isotope effect is studied. A probable mechanism for the observed kinetic data is proposed.

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