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Mechanism of microvesicular steatosis induced by tetracycline: Inhibition of mitochondrial β-oxidation of fatty acids by this antibiotic

Book ID
123286926
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
68 KB
Volume
5
Category
Article
ISSN
0168-8278

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Inhibition of the mitochondrial oxidatio
Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: Possible role in microvesicular steatosis induced by this antibiotic
✍ Eric Fréneaux; Gilles Labbe; Philippe Letteron; The Le Dinh; Claude Degott; Jean 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 831 KB

Intravenous administration of high doses of tetracycline may produce severe microvesicular steatosis of the liver in man. A similar disease is observed after ingestion of drugs which inhibit hepatic mitochondrial fatty acid @-oxidation and in subjects with various inborn defects in this metabolic pa